Although most Americans have eschewed seasonal COVID-19 vaccines, the updated shots continue to show significant protection against cardiovascular disease, especially for those over age 75 and those with underlying medical conditions. That's according to a new study that pulled data from more than 1 million patients in a US Department of Veterans Affairs (VA) health system.

The finding builds on previous data showing that the vaccines significantly lower the risk of COVID-19-associated cardiovascular risks, particularly heart attacks and strokes. But it wasn't a given that the benefit would hold up over time—as the virus evolved, the vaccines were updated, population-level immunity increased from previous infection and vaccination, and risk of severe outcomes fell.

The new study, published in JAMA Internal Medicine, found that the 2024–2025 COVID-19 vaccine continued to protect against COVID-19-associated "major adverse cardiovascular events" (MACE), which include cardiovascular death, heart attack, stroke, and hospitalization for heart failure.

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