A lot of the AI work in biology has been focused on designing proteins. That's partly because proteins do most of the business of life, catalyzing the interesting chemistry and structuring cells. So, figuring out how to make a new protein can mean directly tinkering with biochemistry, providing new and potentially useful functions.

Since the genetic code provides a layer of abstraction between DNA and proteins, it wasn't obvious what a model trained on DNA could do. Yet people went ahead and made a large genome model, and it turned out to be able to output DNA sequences that could encode functional proteins in bacteria and mimic the gene structures found in complex cells. Now, those same models have been used to output the genomes of viruses that infect bacteria.

This isn't science fiction—all the viruses the models created are closely related to an existing virus. But they do have some distinct features that would be challenging to evolve. And the researchers who did the work, based at Stanford University, suggest we may want to start thinking now about preparing for the potential that someone could develop a related AI that can design a virus that targets vertebrates.

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When the history of our ancestry is written, the fact that we've interbred with some of our closest relatives, the Neanderthals and Denisovans, will have a central role. And it will be tempting to write it as a very tidy story: Once we got genomes from these other groups, it was possible to identify the sequences in our genomes that we shared with them.

But in reality, as scientists started poking large enough collections of data, there were regular hints of some strange ancestry in our genomes. It was hard to pin down, though, at least in part because the 2 percent on average of Neanderthal DNA found in many populations does not guarantee that any two individuals will have the same 2 percent. So having the genomes of those two groups made sense of some things researchers had already been seeing.

But knowing what we do about Neanderthal and Denisovan DNA is now allowing researchers to answer a somewhat different question: Is there anything else? Using recently developed analytical techniques, they find evidence of a third lineage that we apparently interbred with before any modern humans left Africa. Again, there were hints of this earlier, but so far, there has been no genome from a modern human relative to help us understand the details—the source of this DNA remains a "ghost lineage."

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